Am J Cardiovasc Dis 2011;1(2):110-118
Review Article
E2F and microRNA regulation of angiogenesis
Dauren Biyashev, Gangjian Qin
Feinberg Cardiovascular Research Institute, Department of Medicine – Cardiology, Northwestern University Feinberg
School of Medicine, Chicago, IL, USA
Received May 20, 2011; accepted June 22, 2011; Epub June 27, 2011; published July 30, 2011
Abstract: E2F family of transcription factors are best known for regulating genes involved in cell cycle control, cell
proliferation, tumorigenesis, and apoptosis. Recent evidences have revealed their critical involvement in modulating
cellular response to hypoxia and ischemia in a variety of physiological and pathological processes. Of particular interest
are findings that E2Fs act as both regulators and targets of microRNAs that govern hypoxic/ischemic angiogenesis. This
review focuses on the crosstalk between E2Fs and microRNAs that have been shown to participate in the regulation of
angiogenesis, hypoxia response and ischemic disease. (AJCD1105005).
Keywords: E2F, microRNA, angiogenesis, ischemia, hypoxia
Full Text PDF
Address all correspondence to:
Gangjian Qin, MD, PhD
Feinberg Cardiovascular Research Institute
Department of Medicine, Cardiology
Northwestern University Feinberg School of Medicine
Chicago, IL, USA
E-mail: g-qin@northwestern.edu
Review Article
E2F and microRNA regulation of angiogenesis
Dauren Biyashev, Gangjian Qin
Feinberg Cardiovascular Research Institute, Department of Medicine – Cardiology, Northwestern University Feinberg
School of Medicine, Chicago, IL, USA
Received May 20, 2011; accepted June 22, 2011; Epub June 27, 2011; published July 30, 2011
Abstract: E2F family of transcription factors are best known for regulating genes involved in cell cycle control, cell
proliferation, tumorigenesis, and apoptosis. Recent evidences have revealed their critical involvement in modulating
cellular response to hypoxia and ischemia in a variety of physiological and pathological processes. Of particular interest
are findings that E2Fs act as both regulators and targets of microRNAs that govern hypoxic/ischemic angiogenesis. This
review focuses on the crosstalk between E2Fs and microRNAs that have been shown to participate in the regulation of
angiogenesis, hypoxia response and ischemic disease. (AJCD1105005).
Keywords: E2F, microRNA, angiogenesis, ischemia, hypoxia
Full Text PDF
Address all correspondence to:
Gangjian Qin, MD, PhD
Feinberg Cardiovascular Research Institute
Department of Medicine, Cardiology
Northwestern University Feinberg School of Medicine
Chicago, IL, USA
E-mail: g-qin@northwestern.edu
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