Am J Cardiovasc Dis 2011;1(2):176-184
Original Article
Echocardiographic findings and abnormalities in HIV-infected patients:
results from a large, prospective, multicenter HIV-heart study
Nico Reinsch, Philipp Kahlert, Stefan Esser, Andreas Sundermeyer, Katrin Neuhaus, Norbert Brockmeyer, Anja Potthoff,
Raimund Erbel, Thomas Buck, Till Neumann for the HIV-HEART Study Investigative Group supported by the German Heart
Failure Network and the Competence Network for HIV/AIDS
Department of Cardiology, West-German Heart Center Essen, University of Duisburg-Essen, Germany; Department of
Dermatology and Venerology, University of Essen, Germany; Department of Dermatology, Ruhr-University Bochum,
Germany.
Received July 3, 2011; accepted July, 2011; Epub July, 2011; published July 30, 2011
Abstract: Aims: The aim of the current study was to assess cardiac structure and function as well as cardiac abnormalities
in a large patient-population based multicenter study of HIV-infected subjects. Materials and methods: We enrolled 803
HIV-positive adults (83.4% men, mean age: 44.2 ± 10.3 yrs) in this prospective, cross-sectional cohort study. The study
protocol included a standardized documentation of patient history, medical treatment and clinical examination. All subjects
underwent a standardized transthoracic echocardiographic examination protocol including Doppler and tissue Doppler
imaging. Results: Echocardiographic measurements revealed a structural dilatation of the left ventricle in 10.1% of all
HIV-infected subjects. Interventricular septum and posterior wall thickness were increased in 18.0% and 11.1%,
respectively, with elevated muscle mass in 14.3% male and 19.4% female patients. Of all participants 13.5% exhibited a
pathologic contraction characteristic of one or more myocardial segments. Prevalence of systolic and diastolic dysfunction
was 34.3% and 48.0%, respectively. However, severe forms of ventricular dysfunction were rare. Conclusions: In
conclusion our results demonstrate the relevance of echocardiography in this patient-population in the era of antiretroviral
therapy. Above all, left ventricular wall thickness and function should be controlled regularly in HIV-infected subjects.
(ClinicalTrials.gov number, NCT01119729). (AJCD1107001).
Keywords: Echocardiography, HIV-Infection, AIDS, cardiomyopathy
Full Text PDF
Address all correspondence to:
Till Neumann, MD, MBA
Department of Cardiology
University of Duisburg-Essen, Medical School
Hufelandstr. 55, 45122 Essen
Germany
Tel: ++49 (0)201 723 4806
Fax: ++49 (0)201 723 5488
Email: till.neumann@uk-essen.de
Original Article
Echocardiographic findings and abnormalities in HIV-infected patients:
results from a large, prospective, multicenter HIV-heart study
Nico Reinsch, Philipp Kahlert, Stefan Esser, Andreas Sundermeyer, Katrin Neuhaus, Norbert Brockmeyer, Anja Potthoff,
Raimund Erbel, Thomas Buck, Till Neumann for the HIV-HEART Study Investigative Group supported by the German Heart
Failure Network and the Competence Network for HIV/AIDS
Department of Cardiology, West-German Heart Center Essen, University of Duisburg-Essen, Germany; Department of
Dermatology and Venerology, University of Essen, Germany; Department of Dermatology, Ruhr-University Bochum,
Germany.
Received July 3, 2011; accepted July, 2011; Epub July, 2011; published July 30, 2011
Abstract: Aims: The aim of the current study was to assess cardiac structure and function as well as cardiac abnormalities
in a large patient-population based multicenter study of HIV-infected subjects. Materials and methods: We enrolled 803
HIV-positive adults (83.4% men, mean age: 44.2 ± 10.3 yrs) in this prospective, cross-sectional cohort study. The study
protocol included a standardized documentation of patient history, medical treatment and clinical examination. All subjects
underwent a standardized transthoracic echocardiographic examination protocol including Doppler and tissue Doppler
imaging. Results: Echocardiographic measurements revealed a structural dilatation of the left ventricle in 10.1% of all
HIV-infected subjects. Interventricular septum and posterior wall thickness were increased in 18.0% and 11.1%,
respectively, with elevated muscle mass in 14.3% male and 19.4% female patients. Of all participants 13.5% exhibited a
pathologic contraction characteristic of one or more myocardial segments. Prevalence of systolic and diastolic dysfunction
was 34.3% and 48.0%, respectively. However, severe forms of ventricular dysfunction were rare. Conclusions: In
conclusion our results demonstrate the relevance of echocardiography in this patient-population in the era of antiretroviral
therapy. Above all, left ventricular wall thickness and function should be controlled regularly in HIV-infected subjects.
(ClinicalTrials.gov number, NCT01119729). (AJCD1107001).
Keywords: Echocardiography, HIV-Infection, AIDS, cardiomyopathy
Full Text PDF
Address all correspondence to:
Till Neumann, MD, MBA
Department of Cardiology
University of Duisburg-Essen, Medical School
Hufelandstr. 55, 45122 Essen
Germany
Tel: ++49 (0)201 723 4806
Fax: ++49 (0)201 723 5488
Email: till.neumann@uk-essen.de
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