Am J Cardiovasc Dis 2012;2(1):20-28
Review Article
SDF-1α and CXCR4 as therapeutic targets in cardiovascular disease
Jessica Wen, Yigang Wang
Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267
USA
Received September 13, 2011; accepted October 11, 2011; Epub December 15, 2011; Published January 1, 2012
Abstract: SDF-1α/CXCR4 signaling is important to endogenous processes, including organogenesis and hematopoeisis,
as well as in responses to tissue injury. The secretion of SDF-1α acts as a chemoattractant to facilitate the homing of
circulating CXCR4 positive cells as well as other stem cells to the site of injury to initiate organ regeneration and repair. In
the case of cardiovascular disease, and particularly myocardial infarction, this signaling axis is implicated in many of these
processes, and has an additional role in providing trophic support for cells and utilizing paracrine mechanisms to enhance
cell survival, promote angiogenesis, and stimulate differentiation. Current research is focused on elucidating these
complex events, and so far have produced promising results that have already led to the development of cell therapies that
can more effectively repair cardiac tissue following ischemic injury than the currently used treatments. Despite these
advancements, much remains to be discovered so that in the future, new treatments will be fined tuned for maximum
tissue regeneration and functional recovery. (AJCD1109002).
Keywords: SDF-1α/CXCR4; Progenitor/stem cells; Cell mobilization; Myocardial infarction; Endothelial cells
Full Text PDF
Address all correspondence to:
Yigang Wang, MD., Ph.D
Department of Pathology and Laboratory Medicine
University of Cincinnati Medical Center
231 Albert Sabin Way
Cincinnati, OH 45267-0529
Phone: (513) 558-5798
FAX: (513) 558-0807
E-mail: yi-gang.wang @UC.Edu
Review Article
SDF-1α and CXCR4 as therapeutic targets in cardiovascular disease
Jessica Wen, Yigang Wang
Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267
USA
Received September 13, 2011; accepted October 11, 2011; Epub December 15, 2011; Published January 1, 2012
Abstract: SDF-1α/CXCR4 signaling is important to endogenous processes, including organogenesis and hematopoeisis,
as well as in responses to tissue injury. The secretion of SDF-1α acts as a chemoattractant to facilitate the homing of
circulating CXCR4 positive cells as well as other stem cells to the site of injury to initiate organ regeneration and repair. In
the case of cardiovascular disease, and particularly myocardial infarction, this signaling axis is implicated in many of these
processes, and has an additional role in providing trophic support for cells and utilizing paracrine mechanisms to enhance
cell survival, promote angiogenesis, and stimulate differentiation. Current research is focused on elucidating these
complex events, and so far have produced promising results that have already led to the development of cell therapies that
can more effectively repair cardiac tissue following ischemic injury than the currently used treatments. Despite these
advancements, much remains to be discovered so that in the future, new treatments will be fined tuned for maximum
tissue regeneration and functional recovery. (AJCD1109002).
Keywords: SDF-1α/CXCR4; Progenitor/stem cells; Cell mobilization; Myocardial infarction; Endothelial cells
Full Text PDF
Address all correspondence to:
Yigang Wang, MD., Ph.D
Department of Pathology and Laboratory Medicine
University of Cincinnati Medical Center
231 Albert Sabin Way
Cincinnati, OH 45267-0529
Phone: (513) 558-5798
FAX: (513) 558-0807
E-mail: yi-gang.wang @UC.Edu
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