Information for Authors

American Journal of Cardiovascular Disease (AJCD, ISSN 2160-200X) is an open access online journal dedicated to
publication of original work in all areas of cardiovascular research. AJCD is primarily devoted to original research papers
(Main Research Articles and Brief Communications), and will also publish traditional Review articles and limited number of
important Case Reports. The goal of AJCD is to provide a forum for rapid dissemination of novel discoveries in basic and
clinical studies on all aspects of cardiovascular disease.

SUBMISSION OF MANUSCRIPT (Click to submit manuscript)

ETHICS AND MALPRACTICE POLICY

Authors’ responsibilities

To ensure that submitted manuscripts have not been published elsewhere (except in the form of an abstract or as part of a
published lecture or thesis) and are not currently under consideration for publication by another journal.

To ensure all authors have contributed to, read and approved the final manuscript for submission.

To ensure that all data in the submitted manuscript are authentic. Maintain accurate records of data associated with their
submitted manuscript and to provide this data upon reasonable request.

To inform the editor of any other submitted manuscripts that might contain overlapping or closely related content.

To obtain permission to reproduce any content from other sources.

To confirm that all the work in the submitted manuscript is original, and to acknowledge and cite any content reproduced
from other sources.

To ensure that any studies involving human or animal subjects conform to national, local and institutional laws and
requirements (e.g. WMA Declaration of Helsinki, the Guidelines of Office for Human Research Protections (OHRP) Human
Subject Protections, NIH Policy on Use of Laboratory Animals, or equivalent). For studies involving human subjects,
authors should obtain express permission from subjects and respect their privacy. Confirmation that approval has been
sought and obtained should be included in the manuscript where applicable. Experiments involving animals should follow
the appropriate institution or the National Research Council Guide for the care and use of laboratory animals.

Declare any potential conflicts of interest that could be perceived as exerting an undue influence on his or her duties at any
stage during the publication process.

To notify promptly the journal editor or publisher if a significant error in their publication is identified, and to cooperate with
the editor and publisher to provide retractions or corrections if necessary.

Keep a copy of the manuscript submitted in case of revision, rejection, loss or damage. Receipt of manuscripts will be
acknowledged and a decision regarding acceptance made as soon as possible. Accepted manuscripts may be subject to
editorial revision without notice.

Authors should provide 4 potential peer reviewers with detailed contact information including e-mail address. Authors may
also nominate 2 peers that they request are not sent the article for peer review for conflicts of interest or other appropriate
reasons – in such instances some reasonable justification must be given. These should be experts in their field of study,
who will be able to provide an objective assessment of the manuscript. If not provided, potential reviewers will be identified
by their publication record or recommended by the Editorial Board members. All manuscripts are subject to peer review
and are expected to meet the rigorous standards of academic excellence.

Reviewers’ responsibilities

To ensure that accepted manuscripts meet the rigorous standards of academic excellence.

To review submitted manuscripts objectively, and in a timely manner.

To maintain the confidentiality of any information supplied by the editor or author, and to not retain or copy the manuscript in
any manner.

To alert the editor of any published or previously submitted content that is substantially similar to that under review.

To point out any relevant published work that is not yet cited.

To be aware of any potential conflicts of interest between the reviewer and author/research funders(financial, institutional,
collaborative or otherwise). To alert the editor to any potential conflicts of interest and if necessary, withdrawing their
services for that manuscript.

Editors’ responsibilities

To act in a balanced, fair and objective way while carrying out duties without discrimination based on sexual orientation,
religious or political beliefs, gender, ethnic or geographical background of the authors. Editors have complete
responsibility and authority to accept and/or reject manuscripts.

Ensure that there is no conflict of interest with respect to manuscripts they reject/accept.

To ensure that all manuscripts, including submissions for sponsored supplements or special issues are handled in the
same way as other submissions, so that articles are considered and accepted solely on their academic merit without any
commercial influence.

To preserve the anonymity of reviewers.

To adopt and follow reasonable procedures in the event of any complaints, ethical or otherwise, in accordance with the
policies and procedures of COPE (www.publicationethics.org). To give authors a reasonable opportunity to respond to any
complaints. All complaints should be investigated no matter when the original publication was approved, and
documentation associated with any such complaints should be retained.

To promote the publication of corrections and/or retractions when errors are found.

Publisher Responsibilities

To ensure that all articles published meet the standards and requirements outlined above.

To ensure that any corrections, retractions, and/or clarifications are published when necessary.

To maintain the integrity of the academic record, and preclude business needs from compromising intellectual and ethical
standards.

Identification of Unethical Behavior

Misconduct and/or unethical behavior may be identified and brought to the attention of the editor and publisher at any time,
by anyone.

Whoever informs the editor or publisher of misconduct should gather sufficient evidence and information in order for an
investigation to be initiated. Evidence should be gathered in a discreet manner, in order to avoid spreading allegations
beyond those who absolutely need to know, in order to protect the confidentiality of the parties in question until a
conclusion has been reached.

All allegations will be taken seriously and handled in the same manner.

The editor will take initial action, with additional input from the publisher where appropriate.

In every case, authors will be given the opportunity to respond to any allegations.

Misconduct and Possible Outcomes

Minor breaches of conduct might be dealt with internally, without the need for any outside consultation;

Depending on the severity of the infraction, other outcomes may include, but are not limited to the following:

Informing the author or reviewer of the infraction, and educating him/her   on how to avoid future breaches of conduct;

A written warning regarding the breach of conduct;

Publication of a formal notice and/or editorial detailing the misconduct;

A formal letter to the author’s department head and/or funding agency;

Retraction of the publication from the journal, and informing both the  Abstracting & Indexing services as well as the
readership of the publication of the infraction;

Suspension of the author’s eligibility for publication;

Reporting the breach of conduct to a higher authority for further investigation and action.

Copyright Policy

By submitting a manuscript to any of e-Century Publishing Corporation journal, all authors agree that all copyrights of
all materials included in the submitted manuscript will be exclusively transferred to the publisher, e-Century Publishing
Corporation once the manuscript is accepted.

Once the paper is published, the copyright will be released by the publisher under the “Creative Commons Attribution
Noncommercial License”, enabling the unrestricted non-commercial use, distribution, and reproduction of the published
article in any medium, provided that the original work is properly cited.
If the manuscript contains a figure or table
reproduced from a book or another journal article, the authors should obtain permission from the copyright holder
before submitting the manuscript,
and be fully responsible for any legal and/or financial consequences if such
permissions are not obtained.

All PDF, XML and html files for all articles published in this journal are the property of the publisher, e-Century Publishing
Corporation (
www.e-Century.org). Authors and readers are granted the right to freely use these files for all academic
purposes. In addition,
the author has the right to reuse any materials in his/her own paper for any purpose without
getting the permission from the publisher
provided that the original work is properly cited.By publishing paper in this
journal, the authors grant the permanent right to the publisher to use any articles published in this journal without any
restriction including, but not limited to academic and/or commercial purposes.

If you are interested in using PDF, html, XML files or any art works published in this journal for
any commercial purposes,
please contact the publisher at business@e-century.org.

Units and Abbreviations

System International (SI) units should be used for all measurements. All abbreviations should be explicitly defined at their
first occurrence except for those internationally acceptable. Abbreviations used in the genetic association reports will need
to follow the conventions detailed in the specific information requirements for genetic association reports. Any articles that
involve the description of enzymes will require the inclusion of the appropriate EC (Enzyme Commission) number as
recommended by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB).

Disclaimer

While the advice and information in the article are believed to be true and accurate on the date of its going to press, neither
the authors nor the editors can accept any legal responsibilities for any errors or omissions that may be made. The
publication makes no warranty, expressed or implied, with respect to the materials contained within.

PREPARATION OF MANUSCRIPT (Click to submit manuscript)

All manuscripts should be written in standard grammatical English using computer software (Arial normal font, size 12,
with single spacing between lines) and should be saved as single DOC (Word) file. Main Research Articles and Brief
Communications will follow a similar format as outlined below while Review Articles will follow a variation on this (see
below).

Main Research Articles are defined as being a substantial novel research study discussing the investigation of a clear
hypothesis or research question with appropriate methodologies (the use of more than one approach is encouraged) and
adequately powered studies and sample sizes. Noting the relevant sections (see below) there is no word limit on
manuscripts of this type except for the Abstract which should be a single unreferenced paragraph and no more than 350
words. There are no limits on the number of display items (tables and/or figures) although authors should try to be concise
and only include the most pertinent information. There are no supplementary tables or figures and every effort should be
made to include these in the main manuscript or alternatively reference should be made in the appropriate locations of the
manuscripts that such information will be available on request from the corresponding authors. There is no limit on the
number of references.

Brief Communications are a format that accommodates the reporting of high quality completed smaller scale studies yet
with important findings. This format is not for the reporting of preliminary or incomplete findings and the review process is
equally rigorous as that for Main Articles. The sections of a Brief Communication follow those of Main Articles (see below)
and there should not be additional sub-headings within these sections.

Review articles have a flexible format, are not of restricted length or reference number. Submissions of reviews must follow
that of Main Research Articles (see below) with the exception that appropriate headings be included for the main text of the
manuscript.

Layout requirements for submissions of Main Research Articles or Brief Communications:

1.        cover letter
2.        title page
3.        abstract and keywords
4.        main text
5.        acknowledgements, if any
6.        Disclosure of conflicts of interest, if any
7.        References
8.        tables, if any
9.        figure legends, if any
10.      figures, if any


Cover Letter

The cover letter should include name, degree, address, telephone, fax and email of the corresponding author. A statement
that all authors have contributed to, read and approved the final manuscript for submission should be included if there are
multiple authors. Any editorial or financial conflict of interest (e.g., consultancy, stock ownership, equity interests, patent or
licensing agreements) should be clearly disclosed in the cover letter. The disclosure statement must be submitted upon
the acceptance. The cover letter should also be used to provide up the relevant details of 4 potential reviewers and 2 non-
reviewers for your manuscript giving appropriate explanations for the latter. Finally, if this submission is following the
solicitation or invitation of an Editorial Board member please state by whom.

Title Page

1.        a concise title;
2.        first name, middle initial, and last name of each author;
3.        name of the department and institutional affiliation of each author.
4.        the email address of each author.(*)
5.        a running title.

(*) AJCD will only use the email address of the designated corresponding author in the final published manuscript but will
use all email addresses supplied to copy in all authors as additional email respondents to the correspondences we
routinely send to acknowledge receipt of manuscripts, and final decisions made on submitted manuscripts. AJCD would
also like, unless otherwise directed in the manuscript covering letter, to use these contact details to announce the contents
lists of future issues of AJCD and its sister journals! At no stage will AJCD sell such email lists to parties external to the e-
Century Publishing Corporation.

Abstract and Keywords

Abstract should not exceed 350 words that concisely summarize the study’s purpose, significant findings and conclusions.
Include up to 10 key words or phrases at the end of the abstract.

Main Text

The main text should include Introduction, Materials and Methods, Results and Discussion. The Introduction should be
succinct, clearly stating the purpose and rationale of the study. In Materials and Methods, the procedures should be
described in sufficient detail to allow duplication by an independent observer. Results and Discussion should be divided.
They should be written concisely and logically with emphasis on novel findings and minimal repetition of text. For genetic
association reports refer to specific information requirements.

Acknowledgements

All acknowledgements (if any) should be included at the end of the main text before references and may include grant and
administrative support.

References (Please download EndNote X Style or Reference Manager Output Style for AJCD)

Reference published in AJCD should begin on a new page, be single-spaced and numbered in order of citation in the text,
including citations in tables and figure legends. Complete author citation is required (use of "et al" is not acceptable).
References should conform to the style of the Journal. Examples follow:

Journals: [1]  Yin M, Hu Z, Tan D, Ajani JA, Wei Q. Molecular epidemiology of genetic susceptibility to gastric cancer: focus
on single nucleotide polymorphisms in gastric carcinogenesis. Am J Transl Res 2009;1:44-54.

Books: Fishman AP: Pulmonary Hypertension and Cor Pulmonale. Pulmonary Diseases and Disorders. Edited by
Fishman AP. New York, McGraw-Hill, 1988, pp. 999-1048

Web sites: Cite in text only using the appropriate URL. It is the author’s responsibility at the time of submission and
subsequent publication that the website address is relevant and functional.

In press: To be used only for papers accepted for publication. Cite as for journal with (in press) in place of volume and
page numbers.

Personal Communications: to be used very sparingly and in the context of no more than one sentence of associated text.

Submitted papers/unpublished data: Cite in text only.

Tables

All tables should be created with Microsoft  Word Table Tool, single spacing between rows and cited consecutively in the
main text by Arabic numbers (Table 1, Table 2, etc). Include each table with a descriptive title on a separate page after the
references. Provide explanations for any nonstandard abbreviations in footnotes to the table.

All tables should be included in the Word File as the part of the complete manuscript after bibliography. Tables in image or
other formats are not acceptable. Authors are encouraged to split extremely large tables into multiple smaller ones to
facilitate publication and easiness to readers.

Figure Legends

Figure legends including figure number, a short title and detailed description should be embedded at the end of text file.

Figures

All figures should be cited consecutively in the main text by Arabic numbers (Figure 1, Figure 2, etc). All figures must be in
TIFF, inserted at the end of the Word file of the manuscript and labeled with the corresponding numbers. The text is all
figures must be in Arial font. Photographs of a person should render them unidentifiable or include their written
permission. Any figures involving Copyright issues should conform to the Copyright policy.

Publication Fees

American Journal of Cardiovascular Disease is an open access journal which provides instant, worldwide and barrier-free
access to the full-text of all published articles. Publication charges allow the publisher to make the published material
available for free to all interested online readers.

The open access publishing fee is $1180 per article. This will be billed to the corresponding author. There is no extra
charge for color figures. Authors who do not have appropriate funds from developing countries can apply to have reduced
fee by submitting a letter signed by the departmental chair to state such a fact.

Manuscript Submission

All manuscripts must be submitted online. Please visit Checking List and then click to submit your manuscript.
AJCD Copyright © 2011-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA