Am J Cardiovasc Dis 2012;2(3):237-247
Review Article
MicroRNAs in ischemia-reperfusion injury
Jakob BW Weiss, Steffen U Eisenhardt, Björn Stark G, Christoph Bode, Martin Moser, Sebastian Grundmann
Department of Internal Medicine III, Department of Plastic and Hand Surgery, University Hospital Freiburg, Germany
Received June 26, 2012; accepted July 21, 2012; Epub July 25, 2012; Published August 15, 2012
Abstract: Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical settings including
myocardial infarction, stroke, and free microsurgical tissue transfer. MicroRNAs (miRNAs, miRs) are short, non-coding
RNA molecules involved in post-transcriptional regulation of gene expression. During the last years they have emerged as
regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Here we give an overview of the
current literature and describe the potential use of miRNA-based therapeutics for the treatment and prevention of
ischemia-reperfusion injury in the future. (AJCD1206008).
Keywords: MicroRNA, ischemia-reperfusion injury, inflammation, acute myocardial infarction, revascularization
Address all correspondence to:
Dr. Sebastian Grundmann
Department of Internal Medicine III (Cardiology and Angiology)
University Hospital Freiburg, Hugstetter Straße 55
79106 Freiburg, Germany.
Tel: +49 761 270 70460; Fax: +49 761 270 70450
E-mail: sebastian.grundmann@ universitaets-herzzentrum.de
Review Article
MicroRNAs in ischemia-reperfusion injury
Jakob BW Weiss, Steffen U Eisenhardt, Björn Stark G, Christoph Bode, Martin Moser, Sebastian Grundmann
Department of Internal Medicine III, Department of Plastic and Hand Surgery, University Hospital Freiburg, Germany
Received June 26, 2012; accepted July 21, 2012; Epub July 25, 2012; Published August 15, 2012
Abstract: Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical settings including
myocardial infarction, stroke, and free microsurgical tissue transfer. MicroRNAs (miRNAs, miRs) are short, non-coding
RNA molecules involved in post-transcriptional regulation of gene expression. During the last years they have emerged as
regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Here we give an overview of the
current literature and describe the potential use of miRNA-based therapeutics for the treatment and prevention of
ischemia-reperfusion injury in the future. (AJCD1206008).
Keywords: MicroRNA, ischemia-reperfusion injury, inflammation, acute myocardial infarction, revascularization
Address all correspondence to:
Dr. Sebastian Grundmann
Department of Internal Medicine III (Cardiology and Angiology)
University Hospital Freiburg, Hugstetter Straße 55
79106 Freiburg, Germany.
Tel: +49 761 270 70460; Fax: +49 761 270 70450
E-mail: sebastian.grundmann@ universitaets-herzzentrum.de
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