Am J Cardiovasc Dis 2013;3(2):85-90
Original Article
Elevated S100A12 and sRAGE are associated with increased length of
hospitalization after non-urgent coronary artery bypass grafting surgery
Ricardo Scheiber-Camoretti, Amit Mehrotra, Ling Yan, Jai Raman, John F Beshai, Marion A Hofmann Bowman
Department of Medicine, Section of Cardiology, The University of Chicago, Chicago Illinois, USA; Department of Surgery,
Section of Cardiothoracic Surgery, The University of Chicago, Chicago Illinois, USA
Received April 4, 2013; Accepted May 15, 2013; Epub June 10, 2013; Published June 15, 2013
Abstract: Study’s purpose: Plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) and S100A12
are increased in young children after cardiac surgery and correlate with the time spent on cardiopulmonary bypass (CPB).
This study was performed to investigate whether plasma levels of sRAGE and S100A12 are affected by the use of CPB.
Levels of S100A12 and sRAGE, along with of interleukin-6, tumor necrosis factor-α, myeloperoxidase, and C-reactive
protein were measured in 25 adults undergoing non-urgent coronary artery bypass grafting with and without the use of
CPB. Significant finding: Plasma levels of S100A12, sRAGE, IL-6, TNF-α and MPO 4h after cardiac surgery were elevated
compared to baseline; this increase was equally observed in patients undergoing traditional coronary artery bypass
grafting on cardiopulmonary bypass (n = 16), and in patients undergoing robot-assisted coronary artery bypass grafting off
pump (OPCAB, n = 9). Patients with prolonged hospitalization of 7 days or longer had significantly higher S100A12 and
sRAGE 4 hours post surgery compared to patients hospitalized ≤ 6 days. Conclusion: Increased sRAGE and S100A12
after cardiac surgery is associated with prolonged length of hospitalization in patients after coronary artery bypass grafting;
however, we did not observe an intrinsic effect of cardiopulmonary bypass on S100A12 or sRAGE plasma levels in our
small pilot study. Further studies are required to confirm the value of sRAGE and S100A12 in predicting postoperative
complications after cardiac surgery in a larger study. (AJCD1304002).
Keywords: Coronary artery bypass graft surgery, S100/calgranulin, sRAGE, biomarker
Address correspondence to: Dr. Marion A Hofmann Bowman, 5841 S. Maryland, MC6080 Chicago, IL 6063. Tel: 773 834
0807; Fax: 773 702 2681; E-mail: mhofmann@medicine.bsd.uchicago.edu
Original Article
Elevated S100A12 and sRAGE are associated with increased length of
hospitalization after non-urgent coronary artery bypass grafting surgery
Ricardo Scheiber-Camoretti, Amit Mehrotra, Ling Yan, Jai Raman, John F Beshai, Marion A Hofmann Bowman
Department of Medicine, Section of Cardiology, The University of Chicago, Chicago Illinois, USA; Department of Surgery,
Section of Cardiothoracic Surgery, The University of Chicago, Chicago Illinois, USA
Received April 4, 2013; Accepted May 15, 2013; Epub June 10, 2013; Published June 15, 2013
Abstract: Study’s purpose: Plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) and S100A12
are increased in young children after cardiac surgery and correlate with the time spent on cardiopulmonary bypass (CPB).
This study was performed to investigate whether plasma levels of sRAGE and S100A12 are affected by the use of CPB.
Levels of S100A12 and sRAGE, along with of interleukin-6, tumor necrosis factor-α, myeloperoxidase, and C-reactive
protein were measured in 25 adults undergoing non-urgent coronary artery bypass grafting with and without the use of
CPB. Significant finding: Plasma levels of S100A12, sRAGE, IL-6, TNF-α and MPO 4h after cardiac surgery were elevated
compared to baseline; this increase was equally observed in patients undergoing traditional coronary artery bypass
grafting on cardiopulmonary bypass (n = 16), and in patients undergoing robot-assisted coronary artery bypass grafting off
pump (OPCAB, n = 9). Patients with prolonged hospitalization of 7 days or longer had significantly higher S100A12 and
sRAGE 4 hours post surgery compared to patients hospitalized ≤ 6 days. Conclusion: Increased sRAGE and S100A12
after cardiac surgery is associated with prolonged length of hospitalization in patients after coronary artery bypass grafting;
however, we did not observe an intrinsic effect of cardiopulmonary bypass on S100A12 or sRAGE plasma levels in our
small pilot study. Further studies are required to confirm the value of sRAGE and S100A12 in predicting postoperative
complications after cardiac surgery in a larger study. (AJCD1304002).
Keywords: Coronary artery bypass graft surgery, S100/calgranulin, sRAGE, biomarker
Address correspondence to: Dr. Marion A Hofmann Bowman, 5841 S. Maryland, MC6080 Chicago, IL 6063. Tel: 773 834
0807; Fax: 773 702 2681; E-mail: mhofmann@medicine.bsd.uchicago.edu
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