Am J Cardiovasc Dis 2013;3(2):79-84
Original Article
Prevalence of aortic dilation in hypertrophic cardiomyopathy
Renuka Jain, Adam Helms, Sharlene M Day, Anna M Booher
Lillehei Heart Institute and Cardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA;
University of Michigan Medical School, Division of Cardiovascular Medicine, Ann Arbor, MI, USA
Received May 7, 2013; Accepted May 22, 2013; Epub June 10, 2013; Published June 15, 2013
Abstract: Recent studies have suggested that hypertrophic cardiomyopathy (HCM) is associated with increased stiffness
of the aorta. However, a potential relationship between HCM and aortic dilation has not been established. Aorta size was
characterized in 223 consecutive patients diagnosed with HCM. Aorta size was measured at the level of the sinuses (n =
223) and ascending aorta (n = 115) using the parasternal long-axis echocardiographic view. Hypertrophy pattern,
maximum wall thickness, and left ventricular outflow tract gradient were measured. Aortic dilation was defined using
previously published criteria that control for body surface area, age, and gender. Mean aorta size among the HCM cohort
was 33.0 ± 5.0 mm at the sinuses and 34.0 ± 5.0 at the tubular aorta. Using the age-based nomogram controlling for body
surface area, 10 (4.5%) of the study population had dilated aortas at the sinuses of Valsalva. Only gender (10/10 male in
dilated group, 127/213 in non-dilated group, p = 0.008) was associated with dilation, while characteristics of HCM (LVOT
obstruction, maximum wall thickness, hypertrophy pattern) were not. Use of other criteria for dilation did not result in an
association with HCM characteristics. Aortic dilation in HCM does not seem to occur more frequently than in the general
population and is not related to the extent of hypertrophy or LVOT obstruction. (AJCD1305001).
Keywords: Aorta, dilation, hypertrophic cardiomyopathy
Address correspondence to: Dr. Renuka Jain, Cardiovascular Division, University of Minnesota, 440 Delaware Street, SE,
MMC 508, Minneapolis, MN 55455. Phone: 612-624-9347; E-mail: rjain@umn.edu
Original Article
Prevalence of aortic dilation in hypertrophic cardiomyopathy
Renuka Jain, Adam Helms, Sharlene M Day, Anna M Booher
Lillehei Heart Institute and Cardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA;
University of Michigan Medical School, Division of Cardiovascular Medicine, Ann Arbor, MI, USA
Received May 7, 2013; Accepted May 22, 2013; Epub June 10, 2013; Published June 15, 2013
Abstract: Recent studies have suggested that hypertrophic cardiomyopathy (HCM) is associated with increased stiffness
of the aorta. However, a potential relationship between HCM and aortic dilation has not been established. Aorta size was
characterized in 223 consecutive patients diagnosed with HCM. Aorta size was measured at the level of the sinuses (n =
223) and ascending aorta (n = 115) using the parasternal long-axis echocardiographic view. Hypertrophy pattern,
maximum wall thickness, and left ventricular outflow tract gradient were measured. Aortic dilation was defined using
previously published criteria that control for body surface area, age, and gender. Mean aorta size among the HCM cohort
was 33.0 ± 5.0 mm at the sinuses and 34.0 ± 5.0 at the tubular aorta. Using the age-based nomogram controlling for body
surface area, 10 (4.5%) of the study population had dilated aortas at the sinuses of Valsalva. Only gender (10/10 male in
dilated group, 127/213 in non-dilated group, p = 0.008) was associated with dilation, while characteristics of HCM (LVOT
obstruction, maximum wall thickness, hypertrophy pattern) were not. Use of other criteria for dilation did not result in an
association with HCM characteristics. Aortic dilation in HCM does not seem to occur more frequently than in the general
population and is not related to the extent of hypertrophy or LVOT obstruction. (AJCD1305001).
Keywords: Aorta, dilation, hypertrophic cardiomyopathy
Address correspondence to: Dr. Renuka Jain, Cardiovascular Division, University of Minnesota, 440 Delaware Street, SE,
MMC 508, Minneapolis, MN 55455. Phone: 612-624-9347; E-mail: rjain@umn.edu
 |  |  |  |  |  |  |
| AJCD Copyright © 2011-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA |